Relation between Hypercholesterolemia and Insulin like growth factor-1 in Elderly Women suffer from Hypothyroidism

Mostafa M. H. Osfor, Mohammad A. Elmadbouly, Samaa S. Elsoadaa, Ahmed H. Metair, Adel A. A. Hussain


The present study included 40 female subjects. They were classified into two groups: group I included 20 females diagnosed as primary hypothyroidism with age ranged between 45 – 65 years and group II included 20 ages matched normal female volunteers and served as control group. Insulin like growth factor -1, (IGF-1) cholesterol, triglycerides, Thyroid stimulating hormone, thyroxine-3 (T3) and thyroxine-4 (T4) hormones were measured in both groups. The obtained results revealed that, there was a significant decrease in IGF-1 level in group I, when compared to control group (P ? 0.01). Correlation studies showed that IGF-1 is strongly positively correlated with T3 (R=0.81, P ? 0.01) and moderately positively correlated with T4 (R= 0.58, P ? 0.05). Meanwhile, it was moderately negatively correlated with cholesterol (R= 0.6, P ? 0.05). The results indicate that IGF-1 deficiency in elder women suffering from ?hypothyroidism may have a direct relation in the pathogenesis of hypercholesterolemia.

Keywords: Hypercholesterolemia: Insulin like growth factor -1: Elderly: Hypothyroidism: growth hormone: thyroid hormone: cholesterol.

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ISSN (Paper)2224-3186 ISSN (Online)2225-0921

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