New RP-HPLC Technique was Development and Validation of Effective and Economical Tool for Quantitative Estimation of Naproxen in Dosage Forms

Vasanth Kumar Kunithala Uma Rani Rondla, Varuni Kollu Divyaja Chatharaju, Sateesh kumar vemula

Abstract


A New RP-HPLC technique was development and validation of effective and economical tool for quantitative estimation of Naproxen in dosage forms rapid, reproducible and selective reverse phase HPLC method has been developed for the estimation of  Naproxen in dosage form.It was resolved by using a mobile phase of Potassium dihydrogen phosphate: methanol in the ratio 30:70 v/v  at a flow rate of 0.8 ml/min. on  HPLC system using UV - Visible detector at the wavelength of  287 nm. The column used was C18 (4.6 x 150mm, 3 mm, Make: Zorbax) .The linearity range was found to be 10-50 ?g/ml. The proposed new method is found to be economic, sensitive, precise, rapid and reproducible.

Keywords:, Naproxen, RP-HPLC, new method development, validation


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ISSN (Paper)2224-3186 ISSN (Online)2225-0921

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