X-Ray Diffraction and structural studies of Cu(II) complex with Gliclazide(N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide),and its hypoglycemic activity

Abstract

Synthesis and characterization by spectroscopic, X-ray and hypoglycemic activity study of copper complex with gliclazide (N-(hexahydrocyclopenta[c]-pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide) an oral antidiabetic drugs.                         The conductometric titration using monovariation method indicate that complex are non-ionic and L₂M (2:1) type. Analytical data agree with the molecular formula (C₁₅H₂₀N₃O₃S)₂Cu. of complex for gliclazide. The structure of complex was assigned square planner supported by IR, ¹H-NMR, X-Ray, mass studies and propose structure (I) for complex.Alloxan induced model have been used to compare hypoglycemic activity of gliclazide complex.

Keywords: Gliclazide, Oral antidiabetic drugs, Complexes, IR, NMR. X-Ray, Hypoglycemic activity.