The Mechanisms Behined the Paradigm of Dysbiosis- Autoimmunity

Abstract

This Dysbiosis –autoimmunity   paradigm may be thoughts as   friend and Foe  partners . The objective of the present , minireview was to elucidate the mechanisms behind  the  dysbiosis-autoimmunity paradigm. Dysbiosis can be initiated by prolonged induction with either one or more of the followings; Boron , mRNA vaccine ,infection ,inflammation ,antibiotics and aging. It is associated with  a characteristic molecular and immune micro-environment encompassing; presence of defective allele encoding immune functions,  intestinal  barrier dysfunction ,tight junction impairment ,and translocant passage. On passing through the impaired intestinal barrier, the translocated pathobiont behaves in either of three ways  ,as reach blood stream through intestinal vascular  barrier ,reach lymphatic circulation through intestinal epithelial barrier or reach Peyres  patchs through  M cell ,then, the interaction with immune mediator molecules and, immune cells  such as ; brook of immune tolerance events, inflammatory-anti-inflammatory cytokine  imbalance, T cell subsets imbalance as T reg./TH1/TH17. Memo-tope, epitope spreading , antigen bystander and stimulating production of autoantibodies or autoreactive cells   possible pointing to autoimmune disease induction . Effector auto-reacting B cell may migrate to lamina propria to produce  autoantibody  there .Effector auto-reacting T cells and T reg. cells may migrate to remote tissue compartments or stay there in.  This theme has well been documented in laboratory animal models but to what extent can be extrapolated to human is still a matter of debate.

Keywords: Autoimmunity, boron, cytokines, dysbiosis, epitope ,gut, memptope pathobiont

DOI: 10.7176/JNSR/17-2-06

Publication date: September 28th 2026