Anti-inflammatory Activity of Ethanolic Leaf Extracts of Thaumatococus Danielli on Iodoacetamide Treated Rats

Babajide Olufemi Elemo, Oluwatosin Benedict Adu, Olasunkanmi Kayode Awote, Gbemisola Morounke Saibu, Olabisi Olufunmilayo Ogunrinola, Adesegun Gideon Adeyemo, Olusegun Omolade Fajana, Muhammed Sheriff Yekini


Anti-inflammatory drugs such as Non-steroidal anti-inflammatory drugs (NSAIDs) are used to reduce swellings and pains caused by inflammation but, long term use of these anti-inflammatory drugs results in the damage of human biological system such as the liver, gastrointestinal tract, etc. Hence, there is need for safer, potent, anti-inflammatory drugs. Hence, the anti-inflammatory activity of ethanol leaf extract of Thaumatococcus danielli on iodoacetamide treated rats was investigated. Forty-two (42) rats were divided into seven groups of six rats each. Group 1 (positive control) received 1ml of 1% CMC; Group 2 (negative control) received 1ml of 1% CMC and 1ml of 0.1% iodoacetamide; Group 3 received 50mg/kg of extract (low dose) and 1ml of 0.1% iodoacetamide; Group 4 received 100mg/kg of extract (high dose) and 1ml of 0.1% iodoacetamide; Group 5 received 50mg/kg of extract (high dose) and 1ml of 1% CMC; Group 6 received 100mg/kg of extract (high dose) and 1ml of 1% CMC; Group 7 received 1ml 1% iodoacetamide and 2.14mg/kg diclofenac. Treatment with T. danielli extract showed no significant difference (p>0.05) in all groups in lymphocyte, RBC, granulocyte, platelet, hemoglobin concentration, hematocrit, mean corpuscular volume and mean corpuscular hemoglobin count but, a significant reduction in all groups was observed in ESR. Moreso, a significant decrease was observed in WBC in the high dose group, and a significant increase in group administered diclofenac.  Ethanolic leaves extract of Thaumaococcus danielli possess an anti-inflammatory potential, possibly due to its embedded phytoconstituents.

Keywords: Thaumatococcus danielli, Anti-inflammatory activity, Hematological studies, Erythrocyte sedimentation rate, Nitric oxide concentration

DOI: 10.7176/JNSR/13-10-03

Publication date:May 31st 2022

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ISSN (Paper)2224-3186 ISSN (Online)2225-0921

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