Molecular Genetic Study of PTC Tasting in Basra Population/Iraq

Abstract

The present study was conducting during 2012-2014. Sequencing of TAS2R38 (P49A) PTC gene 145 C/G) rs713598) among 59 healthy individuals from both sexes and age ranged 30-70 year was studied.  Results showed a present of three genotypes included CC, CG and GG. The first two genotypes were tasters while the third was not taster. The frequency of C and G alleles were 0.55, 0.45 among studied individuals. Genotypic frequencies showed a significant access frequency of heterozygous genotype CG as 0.76 which may implies a selective heterozygous advantage among this region of Iraqi population. A significant differences in genotypic distributions with high incidence of GG genotype (non- taster) among people was recorded.

Keywords: PTC; taste; genetic; polymorphism