Occurrence of Anti- Gonadotropins Hormones Antibodies in Rabbits Immunized with Pseudomonas Aeruginos

Khedhir Hassan Ali, Shurooq Ibrahim Mahmood


The roles of gonadotropins hormones in fertility are well documented. This report deals with the effect of rabbit anti-Pseudomonas aeruginosa immune sera binding and depleting human Leutinizing hormone (LH) and follicle stimulating hormone (FSH). Capturing ELlSA (Pull-down assay) was used to enumerate the depletion potential of immune sera. The finding indicated the presence of anti- hormones antibodies in anti-bacteria immune sera. Percent depletion of males anti-bacteria antisera for (LH) was 35.1 ± 9.6 in test versus 3.3 ± 5.8 control (P=0.001) and for (FSH) was 38.95± 7.96 in test versus 2.1± 1.70 in control (P=0.0001).

On the Other hand, the percent depletion of female anti-bacteria antisera for LH was 10.9±16.9 in test versus 0.6± 1.07 in control, and for FSH was 14.04± 21.79 in test versus 1.075 ± 1.07 for control.

The presence of anti-gonadotropins hormones antibodies generated through immunization with Pseudomonas aeruginosa implicates a role of the immune response to this bacterium in immune-mediated effect in human fertility process.

Keywords: Anti - Gonadotropins, Anti-Hormone antibody, fertility

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ISSN (Paper)2224-3186 ISSN (Online)2225-0921

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