The Immune Overreaction Phenomena in Severe Sars-cov-2 Human Infections

Abstract

The immunology of Sars-cov-2 human infection is known to be complex. One of the facets   of its complexity  is the occurrence  of immune over reaction phenomena  in its severe forms. Such forms stands as  a challenge for laboratory diagnostics and clinicians due its further complexity. The objective of the present mini-review was to explore these immune over-reaction phenomena [IORP ]among the severe infection forms .The noted IORP in severe  covid-19 were as;  two,the innate immno-thrombi [microthrombi]  and the hyper-cytokine-mia[cytokine storm],one cross-road IORP as an unrestrained activation of complement system and two adaptive IORP as an autoimmune phenocopy[ Neutralizing autoantibody producing B cell autoimmune pheno-copy of the type I Interferons ] as well as the Viral sensor [ Dynamics of the MAIT immune cells ]. These phenomena  are resolved on reaching  the possible  case  recovery.

Keywords: Adaptive ,cross-road ,innate ,immune ,over-reaction, phenomena ,sars-cov-2.

DOI: 10.7176/JHMN/85-09

Publication date: January 31^st 2021