Special Imunohistochemical and Histological Demonstration of Neurotoxicological Effects of Regal Dry Gin on Nuclei Aggregation in the Brain Concerned with Motor Functions

Emmanuel O. Adegbite, J.O Sanya


As in most complex systems little disruptions to the brain substance can lead to significant functional disruptions. Properties leading to the susceptibility of nervous tissue include a high surface area of neurons, a high lipid content which retains lipophilic toxins, high blood flow to the brain inducing increased effective toxin exposure, and the persistence of neurons through an individual's lifetime, leading to compounding of damages.[1] As a neurotoxin, alcohol has been shown to induce nervous system damage and affect the body in a variety of ways. Among the known effects of alcohol exposure are both transient and lasting consequences. Some of the lasting effects include long-term reduced neurogenesis in the hippocampus,[2][3] widespread brain atrophy,[4] and induced inflammation in the brain.[5] Since degree of neurodegeneration varies with dosage taken, by some specific immunohistochemical and histological stains we have been able to quantitatively demonstrate the degree of neurodegeneration (nerve cell bodies and fibers degeneration) and extent of and actual apoptosis in acute toxicity of regal dry gin at LD50/14 in brain nuclei aggregations concerned with movement in terms of initiation, processing and coordination.

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ISSN (Paper)2224-3208 ISSN (Online)2225-093X

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