Determination of Anti-schistosomal Finger Profiles of Chenopodium ambrosoide Crude Extracts in BALB/c Mice Using Thin Layer Chromatography (TLC)

Joseph M. Moilo, Joseph M. Keriko, Dorcas S. Yole, Gerald M. Mkoji


Plants may contain ingredients that have anti-parasitic activity against parasites of medical siginificance. Chenopodium ambrosoides (Wormseed) a wide spread herb in the Family: Chenopodiacea was investigated for anti-schistosomal activity using, the human trematode parasite, Schistosoma mansoni, as the target. The plant is well known for its vermifuge and anti-helminthetic properties. The root, stem, leaves and fruit of the plant were extracted sequentially using n-hexane, dichloromethane, methanol and distilled water as solvents and tested for anti-schistosomal activity. TLC finger profiles mobile of C. ambrosoides extracts showed aqueous (leaf) extract had  more Rf spots than methanol (fruit) extract but they were not significantly different (P > 0.05). The results of this study suggest that Chenopodium ambrosoides aqueous (leaf) and methanol (fruit) extracts has remarkable anti-schistosomal properties, and should be investigated to determine their toxicity and also tested against other parasites as a source novel anti-parasitic compounds.

Keywords: Rf - Mobility Relative to front TLC - Thin Layer Chromatography

Full Text: PDF
Download the IISTE publication guideline!

To list your conference here. Please contact the administrator of this platform.

Paper submission email:

ISSN (Paper)2224-3224 ISSN (Online)2225-0956

Please add our address "" into your email contact list.

This journal follows ISO 9001 management standard and licensed under a Creative Commons Attribution 3.0 License.

Copyright ©