Improvement of lung cancer radiotherapy using gold nanoparticles and gamma ray photons with high energy.

Abstract

Since the lung tissue has small cross section so that we can introduce an agent to enhance the local cross section. Among nanomaterials gold nanoparticles (GNPs) has significant attention because their physical and biological properties. Like it has high absorb to gamma ray photons when it irradiate by external gamma ray compared to lung tissue so gold nanoparticles are used in local dose enhancement in lung tumor during external radiotherapy. In the present study we estimate the dose enhancement by simulation program for several concentrations of gold nanoparticles (GNPs) interact with high energy photons, by consider entity the gold nanoparticles in lung cancer tumor  then irradiate by gamma ray photons with energy 12 Mev. The results showed enhancing in absorbed dose. This enhancement represent by increasing in destroyed cancer cells and it depending on concentration of gold nanoparticles (GNPs) within the lung cancer tumor and gamma ray photons with high energy.

Key Words: Gold nanoparticles (GNPs) , Radiotherapy, Dose enhancement, lung cancer , External gamma photon.