Comparative Computational Analysis of Mycobacterium Species by using Different Techniques in Study

Abstract

Mycobacterium tuberculosis (MTB) is a pathogenic bacteria species in the genus Mycobacterium and the causative agent of most cases of tuberculosis. It is spread through the air when people who have an active MTB infection cough, sneeze, or otherwise transmit their saliva through the air. Most infections in humans result in an asymptomatic, latent infection, and about one in ten latent infections eventually progresses to active disease, which, if left untreated, kills more than 50% of its victims.  Mycobacterium tuberculosis is a member of the genus ‘tuberculosis’ in which contains various other mycobacterium species also. These species within a gene must have some similarity in them. In spite of this similarity only mycobacterium tuberculosis cause the tuberculosis disease, the remaining does not. This signifies that mycobacterium tuberculosis must be having some specific genes or proteins which are uniquely present only in it and not in the other species. This fact is used in this research and blast program is executed recursively for the comparison between these mycobacterium species.

Keywords: BLAST, Mycobacterium Tuberculosis, Nontuberculous mycobacterium group, EEA1, KEGG