Synthesis and Structural Studies of O-vanillin Indomethacin Hydrazone and P-vanillin Indomethacin Hydrazone

Abstract

Three steps of two novel ligands of Indomethacin hydrazide based Schiff bases ligands were synthesized. For our targeted ligands, first we synthesized Indomethacin Ethyl Ester (RCOOC₂H₅), This ester was further reacted with hydrazine hydrate to produce Indomethacin acid hydrazide (RCONHNH₂). Finally, this hydrazide condensed with o-Vanillin and p-Vanillin to get targeted compounds. Structure confirmation was characterized based on IR, ¹H-NMR and ¹³C-NMR spectroscopy.

Keywords: NSIADs, Indomethacin, o-Vanillin, p-Vanillin, acid hydrazide, Hydrazone, transition metal complexes, Hydrazide Base Schiff Bases.