Synthesis and Structure Activity Relationships of Eusiderin A Derivatives as Antifeedant

Syamsurizal ., Afrida .


Eusiderin A(1) which isolated from Eusideroxylon zwagery was converted into some derivatives(2- 10)in order to disclose the structure activity relationship as antifeedant. The structures of these compounds were determined based on their spectroscopic data including 1H NMR, COSY, and NOESY spectra and mass spectra. The antifeedant activity and Brine Shrimp Lethality test  have been evaluated to demonstrate that 2, 3, 6 and 7 increased significantly the antifeedant activity rather than eusiderin A,  while all of the analogs were classified as non toxic.

Keywords: eusiderin A, E. sparsa, antifeedant, brine shrimp lethality test.

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ISSN (Paper)2224-3224 ISSN (Online)2225-0956

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