Synthesis and Characterization of Cobalt Homotrinuclear Biologically Active Compound

Abstract

N₄O₃ tripodal Schiff-base ligand namely tris(5-Bromo-2-hydroxybenzylaminoethyl)amine (Tren5BrSal) have been prepared and characterized by various spectroscopic methods . It is derived from the condensation reactions of tris(2-aminoethyl)amine (Tren), with 3 equivalents of 5-bromo-2-hydroxybenzaldehyde (5BrSal). The Cobalt(III) complex of the resulting ligand was obtained from the reaction of Tren5BrSal with the salt of  cobalt in absolute methanol. The antimicrobial screening was carried out against two bacterial species (Escherichia coli and Streptococc. Sp) and two fungal species (Aspergillus niger and Fusarium sp.). The complex is found to exhibit high antibacterial and anti fungal activity.

Keywords: Schiff- base, tris-(2-aminoethyl)amine, Tren5Brsal, Cobalt.