Role of vascular endothelial growth factor receptors in the pathogenesis of psoriasis

Abstract

Background : Psoriasis is a chronic immune-inflammatory-mediated disease characterized by epidermal hyperplasia and angiogenesis. Recently, vascular endothelial growth factor receptors (VEGFRs, including VEGFR-1, VEGFR-2 and VEGFR-3) were found to be expressed in normal human epidermis and associated with proliferation and migration of keratinocytes.

Objective: The purpose of this study is to investigate the serum level of vascular endothelial growth factor receptors (sVEGFR1 and sVEGFR2) in psoriatic patients

Methods: 100 consenting psoriatic patients(males and females) aged 20-60 years who attended out patients clinic of dermatology in Al-Sadr Medical City in AL-Najaf city -Iraq. Psoriasis area and severity index assessment was done for each patient. Blood samples was collected for vascular endothelial growth factor receptor 1 and receptor 2 measurement.

Result: The serum level of vascular endothelial growth factor receptor 1 in addition to receptor 2 were significantly increased in all group of psoriatic patients compared to healthy controls (P<0.001) .

Conclusion: The serum level of vascular endothelial growth factor receptor 1 in addition to receptor 2 had significant role in evolution of psoriatic plaque.

Keywords: Serum vascular endothelial growth receptor 1, Serum vascular endothelial growth receptor 2,Psoriasis area and severity index, Psoriasis.

List of abbreviation: sVEGFR= serum vascular endothelial growth receptor, PASI = Psoriasis area and severity index, SD=standard deviation , ECs=endothelial cells. ELISA= Enzyme Linked Immuno Linked Sorbant Assay.