Changes in Aortic Vasa Vasorum Associated with Rabbits Hyperimmunization with Pseudomonas Aeruginosa

Abstract

Aortic adventitial vasa vasorum (vv) is an essential network of microvesseles that participates in providing nutrient , oxygen , besides being a source of stem cell for neovascularization (vv) is involved in inflammatory response in atherosclerosis . Male rabbits were immunized with heat killed , Whole bacteria, rested for two weeks and aortic base region were processed for histological examination . In addition  the sex-steriods hormonal levle were estimated by ELISA . The results demonstrated that immunized rabbit showed prominent thickened tunica media with signs of smooth muscle cell proliferation . The most interesting findings included increased angiogenesis . Rabbits showing these changes demonstrated increased testosterone 5.77± 3.78 in test versus 1.25 ±  0.87 in control (P=0.089) . progesterone and estradiol didn’t show any changes in test animals . These results implicate that contineous exposure to bacterial constituents  could  induce atherosclerotic lesion in aorta vasa vasorum.

Keywords:Vasa Vasorum (VV) , Immunization, Pseudomonas aeruginosa