Synthesis and anticancer activity evaluation of Novel 6 mercaptopurine derivatives.

Abstract

A series of five (6- mercaptopurine derivatives) have been synthesized as disulfide, Schiff base, Oxadiazole and amide products and the activity as anticancer was evaluated against three types of cancer lines. The pilot studies indicated that compound 1, 2, 3, 4 and 5 were the active compounds, but only compound (1) reviewed in detail .The reaction progress and products purity were checked by thin layer chromatography. The target chemical structures of compounds and intermediates were proved by their physicochemical properties as melting points, infrared spectroscopy, and elemental microanalysis (CHNS) and proton nuclear magnetic resonance (H1NMR) 

Keywords: cancer, 6 -mercaptopurine, disulfide, penicillamine