Metal Ion Effect on the Absorbance Response of Chlorpheniramine Maleate in Pharmaceutical Dosage Form: A Study on Correlation between Spectroscopic and Potentiometric Measurements

Abstract

The interference between metal ions in human body and drug molecules is highly serious. A widely used drug by children and adults to treat throat pain and tonsillitis has been studied. The absorbance intensity of Chlorpheniramine Maleate drug in the presence of Fe³⁺, Co⁺², Ca⁺² and Mg⁺² metal ions has been studied. The addition of Fe³⁺, Co⁺², Ca⁺² and Mg⁺² metal ions to an aqueous solution of chlorpheniramine maleate increases the absorbance signal significantly and rapidly. These metals are chosen because they have high concentration in human body. Increasing the pH value of the aqueous solution of chlorpheniramine maleate has a contrary effect on the absorbance signal. Potentiometric measurements have been performed to correlate the spectrophotometric results and found to be consistent. Potentiometric and spectrophotometric measurements prove that there is a change in drug concentration at different pH value and to think carefully when using such drugs.

Keywords: Chlorpheniramine Maleate, spectrophotometric and Potentiometric measurements.