Synthesis, Characterization and Biological Activity of Mixed Ligands Complex of Co (Ii) Ions with Succinic Acid and Hexamethylenetetramine

Abstract

Novel Co(II) complex with hexamethylenetetramine and succinic acid as ligands has been synthesized using slow evaporation method. The complex has been characterized by Fourier transform infrared, electronic spectra and elemental analyses. The nature of bonding and the stereochemistry of the complex have been deduced from infrared and electronic spectra measurements. Based on the study results a tetrahedral geometry has been proposed for this complex, in which the central metal ion is bonded to the ligands through hydrogen-bonding. The antibacterial activity has been evaluated by the disc diffusion method against five pathogenic bacteria (one gram positive and four gram negative). The biological activity data indicate that the metal complex showed enhanced inhibitory activity compared to the parent ligands. The present work relates to metal organic framework material which possesses anti-microbial properties to prevent or treat microbial infections, or provide surfaces which limit contamination by micro-organisms.

Keywords: Hexamethylenetetamine, succinic acid; biological activities; polymer