Chemistry and Materials Research
Synthesis, Characterization and Biological Study of Some New 1,3-Oxazolone-5(4H)-one Derivatives
Abstract
New 1,3-oxazol-5(4H)-one (oxazalone) have been synthesized by reaction 2-amino acid (glycine) with sebacoyl chloride. These compounds were characterized by CHN, IR and 1HNMR spectroscopy.The present study showed that the our compounds more efficient than all antibiotics against gram positive bacteria Staph. areus and E.coli compared with all antibiotics except Gentamycin more efficient than compounds1&3 in against gram negative E.coli (18 mm).T- test shows signifying differences between our compounds of present study and antibiotics (P<0.01).
Keywords :oxazolone, Erlenmeyer Plochl reaction
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ISSN (Paper)2224-3224 ISSN (Online)2225-0956
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